教育经历

• 2002－2007年，复旦大学，光科学与工程系，理学博士

• 2003－2004年，美国Eastern Michigan University，物理系，访问学者

• 1998－2002年，复旦大学，物理系，理学学士

• 2001年6－8月，台湾新竹清华大学物理系，两岸交流“莙政学者”

工作经历

• 2011至今，复旦大学，光科学与工程系，副教授

• 2012年，美国Temple University，生物系，博士后

• 2011年，美国Bowling Green State University, 生物系，博士后

• 2007－2011年，复旦大学，光科学与工程系，讲师

科研方向

• 1、共焦显微镜、双光子激发荧光显微系统的生物成像以及相关的物理问题

• 2、荧光寿命成像在生物中的应用

• 3、基于成像和机器学习的癌症早期诊断

• 4、基于超分辨显微镜的成像算法、显微图像的机器学习

• 5、光学探针、纳米荧光颗粒和生物靶向性纳米材料在生物医学研究中的应用

主持项目

• 2022 国家自然科学基金 （62175036）

• 2021 烟台留学人员创业园项目

• 2021 复旦大学医工结合项目(双一流)

• 2018 科技部(国际合作) (SINO-SERBIA2018002)

• 2016 国家自然科学基金（11574056）

• 2014 教育部留学回国人员科研启动基金

• 2013 复旦大学人才计划“卓学计划”

• 2013 复旦大学中央高校青年教师科研能力提升项目

• 2011 国家自然科学基金-青年（61008055）

• 2011 教育部博士点基金（20100071120029）

• 2008 上海市教委人才计划“晨光”项目(2008CG03)

• 参与项目还包括多项国家自然科学基金、上海市卫生和计划生育委员会科研课题等

奖励

• 第六届睿郡奖教金科研成果二等奖 2023

• 第五届睿郡奖教金科研成果二等奖 2022

• 第四届睿郡奖教金科研成果二等奖 2021

科研成果

近几年部分文章、专著：(*corresponding author)

1. Mingmei Ji, Yulan Wang, Wenhua Su, Liwen Chen, Yuzhe Liu, Yuwei Yang, Yiyan Fei, Jiong Ma*, Ying Chen* and Lan Mi*, Enhancing the photodynamic effect of curcumin through modification with TiO₂ nanoparticles and cationic polymers, J. Photochem. Photobio. B, 252, 112851 (2024)

2. Han Sheng, Liwen Chen, Yinping Zhao, Xiangao Long, Qiushu Chen, Chuanyong Wu, Bei Li, Yiyan Fei, Lan Mi*, Jiong Ma*, “Closed, one-stop intelligent and accurate particle characterization based on micro-Raman spectroscopy and digital microfluidics”, Talanta, 266, 124895 (2024)

3. Yawei Kong,Jianpeng Ao,Qiushu Chen,Wenhua Su,Yinping Zhao,Yiyan Fei,Jiong Ma,Minbiao Ji*,Lan Mi*,Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-free Microscopy System and Machine Learning, Cells, 12, 1524 (2023)

4. Qiushu Chen, Qi Meng, Yuzhe Liu, Xiangan Long, Yawei Kong, Longfang Yao, Liwen Chen, Chuanyong Wu, Kaiqin Chu, Lan Mi, Jiang Ma*, “A digital microfluidic single-cell manipulation system optimized by extending-depth-of-field device”, Journal of Innovative Optical Health Sciences, (2023) 2244006

5. Hang Zhang; Mengjing Xu; Haofeng Li; Xiaohan Mai; Jiawei Sun; Lan Mi; Jiong Ma; Xiangdong Zhu; Yiyan Fei*, “Detection speed optimization of the OI-RD microscope for ultra-high throughput screening”, Biomedical Optics Express,2023, 14(5): 2386
   

6. Wenhua Su, Dan Yang, Yulan Wang, Yawei Kong, Wanlu Zhang, Jing Wang, Yiyan Fei, Ruiqian Guo*, Jiong Ma*, Lan Mi*, “AgInS2/ZnS quantum dots for noninvasive cervical cancer screening with intracellular pH sensing using fluorescence lifetime imaging microscopy”, Nano Research, 15, 5193–5204 (2022).

7. Xingyu Gong, Li Zhou, Longfang Yao, Li Zhang, Liwen Chen, Yiyan Fei, Lan Mi*, Baoju Wang* and Jiong Ma*. Achieving increased resolution and reconstructed image quality with intensity and gradient variance reweighted radial fluctuations, ACS Photonics, 9, 5, 1700–1708 (2022).

8. Mingmei Ji, Jiahui Zhong, Runzhe Xue, Wenhua Su, Yawei Kong, Yiyan Fei, Jiong Ma, Yulan Wang* and Lan Mi*, “Early Detection of Cervical Cancer by Fluorescence Lifetime Imaging Microscopy Combined with Unsupervised Machine Learning”, Int. J. Mol. Sci. 23, 11476 (2022).

9. Y. Kong, Y. Zhao, Y. Yu, W. Su, Z. Liu, Y. Fei, J. Ma, Lan Mi*, “Single cell sorting of young yeast based on label-free fluorescence lifetime imaging microscopy”, J. Biophotonics 15(4), e202100344, (2022). (Inside Cover)

10. Zhao, Y.; Kong, Y.; Chen, L.; Sheng, H.; Fei, Y.; Mi, L.*; Li, B.*; Ma, J.* Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro. Molecules 27, 3582 (2022).

11. Han Sheng, Yinping Zhao, Xiangan Long, Liwen Chen, Bei Li, Yiyan Fei, Lan Mi*, Jiong Ma*, Visible Particle Identification Using Raman Spectroscopy and Machine Learning, AAPS PharmSciTech  23:186(2022).

12. Saira Hameed*, Kun Pan, Wenhua Su, Miles Trupp, Lan Mi, Jinzhuo Zhao*, Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury, Part. Fibre Toxicol. 19:51 (2022).

13. Liu Y, Chen Q, Fei Y*, Mi L* and Ma J*, Design of an ellipsoidal mirror assisted oblique plane microscopy. Front. Phys. 10:1057002 (2022)

14. Xinyue Liang, Yonghui Xie, Junxin Wu, Jing Wang, Marijana Petkovic, Milutin Stepic, Jinzhuo Zhao*, Jiong Ma*, Lan Mi*, “Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo”, J. Photochem. Photobio. B 215, 112122 (2021)

15. Kai Guo, Junxin Wu, Yawei Kong, Li Zhou, Wei Li, Yiyan Fei, Jiong Ma*, Lan Mi*, “A label-free and noninvasive method for assessing the metabolic status in type 2 diabetic rats with myocardium diastolic dysfunction”, Biomedical Optics Express 12(1): 480-493 (2021)

16. Li Zhou, Yawei Kong, Junxin Wu, Xingzhi Li, Yiyan Fei, Jiong Ma, Yulan Wang* and Lan Mi*,  “Metabolic Changes in Maternal and Cord Blood in One Case of Pregnancy-Associated Breast Cancer Seen by Fluorescence Lifetime Imaging Microscopy”, Diagnostics 11(8), 1494 (2021)

17. Yulan Wang, Xinyue Liang, Hui Wang, Li Li, Guoping Xiong* and Lan Mi*, “A considerable asymptomatic proportion and thromboembolism risk of pregnant women with COVID-19 infection in Wuhan, China”, Journal of Perinatal Medicine, 49(2), 237-240 (2021)

18. Longfang Yao, Li Zhang, Yiyan Fei, Liwen Chen, Lan Mi* and Jiong Ma*, “Application of SNAP-Tag in Expansion Super-Resolution Microscopy Using DNA Oligostrands”, Front. Chem. 9, 640519 (2021)

19. Longfang Yao, Li Zhang, Liwen Chen, Xingyu Gong, Jiahui Zhong, Baoju Wang, Yiyan Fei, Lan Mi* and Jiong Ma*, “Dynamic Structure of Yeast Septin by Fast Fluctua-tion-Enhanced Structured Illumination Microscopy”, Microorganisms 9(11), 2255 (2021)

20. Liwen Chen, Longfang Yao, Li Zhang, Yiyan Fei, Lan Mi* and Jiong Ma*, “Applications of Super Resolution Expansion Microscopy in Yeast”, Front. Phys. 9, 650353 (2021)

21. Milica Matijević, Jelena Žakula, Lela Korićanac, Marija Radoičić, Xinyue Liang, Lan Mi, Jelena Filipović Tričković, Ana Valenta Šobot, Maja N. Stanković, Đura Nakarada, Miloš Mojović, Marijana Petković, Milutin Stepić, Maja D. Nešić, “Controlled killing of human cervical cancer cells by combined action of blue light and C‑doped TiO2 nanoparticles”, Photoch. Photobio. Sci. 20, pages1087–1098 (2021)

22. Chengrui Zhang, Yi Zhou, Lan Mi, Jiong Ma , Xiang Wu and Yiyan Fei *, “High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating”, Biosensors, 11, 221 (2021)

23. Yueyue Jing, Yilin Lv, Jingya Ye, Longfang Yao, Liwen Chen, Lan Mi, Yiyan Fei, Yao Yu, Biao Dong*, Hong Lv*, Jiong Ma*, Quantifying tagged mRNA export flux via nuclear pore complexes in single live cells, Biochem. Bioph. Res. Co., 545, 138-144 (2021)

24. Baoju Wang, Zhijia Liu, Li Zhou, Yiyan Fei, Chengliang Yang, Lan Mi*,  Quanquan Mu*  and  Jiong Ma*，“Active-modulated, random-illumination, super-resolution optical fluctuation imaging”，Nanoscale, 2020, 12, 16864-16874.

25. Jing Wang, Han Zhang, Xiao Xiao, Liang Dong, Xinyue Liang, Lan Mi*, Jianfang Wang*, Jun Liu*, “Gold nanobipyramid-loaded black phosphorus nanosheets for plasmon-enhanced photodynamic and photothermal therapy of deep-seated orthotopic lung tumors”, Acta Biomater. , 107, 260-271, (2020)

26. Maojia Huang, Xinyue Liang, Zixiao Zhang, Jing Wang, Yiyan Fei, Jiong Ma*,Songnan Qu* and Lan Mi*, “Carbon Dots for Intracellular pH Sensing with Fluorescence Lifetime Imaging Microscopy”, Nanomaterials, 10(4), 604 (2020)

27. Xinyi Wang, Yulan Wang, Zixiao Zhang, Maojia Huang, Yiyan Fei, Jiong Ma*, Lan Mi*, "Discriminating different grades of cervical intraepithelial neoplasia based on label-free phasor fluorescence lifetime imaging microscopy", Biomedical Optics Express, 11(4), 1977-1990 (2020)

28. B.Wang, L. Yao, Y. Jing, Y. Fei, Q. Bai*, Lan Mi*, J. Ma*, “Multicomposite super-resolution microscopy: Enhanced Airyscan resolution with radial fluctuation and sample expansions”, J. Biophotonics, e2419, (2020)

29. Maja D. Nešić, Tanja Dučić, XinyueLiang, Manuel Algarra , Lan Mi, Lela Korićanac,  Jelena Žakula, Tatjana J. Kop, Mira S. Bjelaković, Aleksandra Mitrović, Gordana D. Gojgić  Cvijović, Milutin Stepić, Marijana Petković, SR-FTIR spectro-microscopic interaction study of biochemical changes in HeLa cells induced by Levan-C60, Pullulan-C60, and their cholesterol-derivatives, International Journal of Biological Macromolecules, 165, 2541-2549 (2020)

30. Milica Matijević, Đura Nakarada, Xinyue Liang, Lela Korićanac, Lenka Rajsiglova, Luca Vannucci, Maja Nešić, Mila Vranješ, Miloš Mojović, Lan Mi, Irina Estrela-Lopis, Julia Böttner, Zoran Šaponjić, Marijana Petković, Milutin Stepić, Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer, J. Nanopart. Res. 22:175 (2020)

31. X.L. Liu, B.J. Wang, L. F. Yao, Y. Y. Fei, L. Mi*, J. Ma*, “3D particle tracking using a dual-objective fluorescent reflection system with spherical aberration”, J. Phys. D: Appl. Phys. 52, 385403, (2019).

32. Xiaolan Liu, Longfang Yao, Weidong Yang, Yiyan Fei, Lan Mi*, and Jiong Ma*, “Spectroscopic fluorescent tracking of a single molecule in a live cell with a dual-objective fluorescent reflection microscope”, Appl. Phys. Exp., 12, 112007 (2019)

33. Xinyi Wang, Yonghui Xie, Huang Maojiao, Yao Longfang, Yulan Wang, Yiyan Fei, Jiong Ma*, Lan Mi*, “Effect of Fixation and Mounting on Fluorescence Lifetime of Cellular Autofluorescence”, IEEE J. Sel. Top. Quant., 25(1): 7202606 (2019)

34. Maojia Huang, Zixiao Zhang, Xinyi Wang, Yonghui Xie, Yiyan Fei, Jiong Ma, Jing Wang, Li Chen, Lan Mi*, Yulan Wang*, “Detecting benign uterine tumors by autofluorescence lifetime imaging microcopy through adjacent healthy cervical tissues”, J. Innov. Opt. Healt. Sci., 12(5), 1940006 (2019)

35. Yueyue Jing, Yulan Wang, Xinyi Wang, Chuan Song, Jiong Ma, Yonghui Xie, Yiyan Fei,  Qinghua Zhang*, Lan Mi*, “Label-free imaging and spectroscopy for early detection of cervical cancer”, J. Biophotonics , 11(5):e201700245 (2018)

36. Lan Mi, Longfang Yao, Jiong Ma*, Nuclear Cytoplasmic Transport ,Chap2 Structure of Yeast Nuclear Pore Complexes, Springer International Publishing AG, 2018

37. Jing Wang, Shimiao Wang, Lan Mi*, and Jun Liu*, “Aspect ratio dependence of the enhancement of fluorescence intensity by gold nanobipyramids for cancer cell imaging and photodynamic therapy”, Laser Phys. 2018, 28, 075602

38. C. G. Zhu, G. L. Ge, R. Chen, X. D. Zhu, L. Mi, J. Ma, X. Wang, F.Y. Zheng, Y. Y. Fei*, Fast focal point correction in prism-coupled total internal reflection scanning imager using an electronically tunable lens, Sensors, 18, 524, (2018).

39. J. W. Hu, R. Chen, C. G. Zhu, B. L. Ge, X. D. Zhu, L. Mi, J. Ma, C. Q. Han, H. Chen*, Y. Y. Fei*, Label-free Microarray-based binding affinity constant measurement with modified fluidic arrangement, BioChip. J. 12, 11, (2018).

40. Xiaobo Pan, Xinyue Liang, Longfang Yao, Xinyi Wang, Yueyue Jing, Jiong Ma, Yiyan Fei, Li Chen and Lan Mi*, “Study of the Photodynamic Activity of N-Doped TiO2 Nanoparticles Conjugated with Aluminum Phthalocyanine”, Nanomaterials, 7, 338 (2017).

41. Mengyan Wang, Feng Tang, Xiaobo Pan, Longfang Yao, Xinyi Wang, Yueyue Jing, Jiong Ma, Guifang Wang, and Lan Mi*, "Rapid Diagnosis and Intraoperative Margin Assessment of Human Lung Cancer with Fluorescence Lifetime Imaging Microscopy", BBA Clinical, 8, 7-13 (2017).

42. Mengyan Wang, Feng Long, Feng Tang, Yueyue Jing, Xinyi Wang, Longfang Yao, Jiong Ma, Yiyan Fei, Li Chen, Guifang Wang, and Lan Mi*, “Autofluorescence Imaging and Spectroscopy of Human Lung Cancer”, Applied Science, 7, 32 (2017).

43. R. Chen, C. G. Zhu, G. L. Ge, X. D. Zhu, Y. S. Sun, L. Mi, J. Ma, X. Wang, Y. Y. Fei*, Detecting signals with direct Fast Fourier Transform for microarray data collection, IEEE Photonic. Tech. L. 29, 2211 (2017).

44. Jin Xie, Xiaobo Pan, Mengyan Wang, Jiong Ma, Yiyan Fei, Pei-Nan Wang, Lan Mi*, “The Role of Surface Modification for TiO2 Nanoparticles in Cancer Cells”, Colloid. Surface. B, 143, 148-155 (2016).

45. Jin Xie, Xiaobo Pan, Mengyan Wang, Longfang Yao, Xinyue Liang, Jiong Ma, Yiyan Fei, Pei-Nan Wang, Lan Mi*, “Targeting and Photodynamic Killing of Cancer Cell by Nitrogen-Doped Titanium Dioxide Coupled with Folic Acid”, Nanomaterials 6, 113 (2016)

46. Yulan Wang, Chuan Song, Mengyan Wang, Yonghui Xie, Lan Mi*, and Guifang Wang “Rapid, Label-free and Highly Sensitive Detection of Cervical Cancer with Fluorescence Lifetime Imaging Microscopy”, IEEE J. Sel. Top. Quant. , 22(3), 6801307 (2016).

47. Xiaobo Pan, Jin Xie, Zheng Li, Maxin Chen, Mengyan Wang, Pei-Nan Wang, Li Chen and Lan Mi*, “Enhancement of the photokilling effect of aluminum phthalocyanine in photodynamic therapy by conjugating with nitrogen-doped TiO2 nanoparticles”,  Colloid. Surface. B, 130, 292-298 (2015)

48. Lan Mi, Alexander Goryaynov, Andre Lindquist, Michael Rexach, Weidong Yang, “Quantifying Nucleoporin Stoichiometry Inside Single Nuclear Pore Complexes In vivo”, Scientific Reports, 5, 9372 (2015)

49. Xiaobo Pan, Zheng Li, Tianlong Wang, Jin Xie, Pei-Nan Wang, Ji-Yao Chen, Li Chen, Lan Mi* “Study of polycation-capped Mn:ZnSe quantum dots as a novel fluorescent probe for living cells”, J. Fluo.,24(3),767-774 (2014)

50. Zheng Li, Lan Mi*, Pei-Nan Wang, and Ji-Yao Chen, “Comparison of the killing effects between nitrogen-doped- and pure-TiO2 on HeLa cells with visible-light irradiation”, Nanoscale Res. Lett.,8, 96 (2013).

教授课程

• 本科生课程：《大学物理》、《近代物理》、《光生物医学》、《专业实验》

• 研究生课程：《激光光谱学》、《生物光子学》

小组成员已毕业去向：

• 2008 张  豫  博士 (上海市优秀博士论文，2009年王大珩光学奖)  英国剑桥大学

• 2011 熊蓉玲  硕士 (2011上海市优秀毕业生)   科磊半导体设备技术有限公司

• 2013 李  征  博士 (2013上海市优秀毕业生)   上海和辉光电有限公司

• 2014 王天珑  硕士 华为技术有限公司

• 2016 潘晓波  博士 上海盛知华知识产权服务有限公司

• 2016 解  晋  硕士 科磊半导体设备技术有限公司

• 2016 宋  川  本科望道项目 美国宾夕法尼亚大学

• 2017 王梦妍 硕士 (2016全国研究生数学建模竞赛一等奖) 上海斐讯数据通信有限公司

• 2018 梁馨月 本科莙政项目 复旦大学直升研究生

• 2019 王欣怡 硕士 (2019校优秀毕业生，2018研究生数学建模三等奖)  上海天跃科技股份有限公司

• 2020 黄茂佳 硕士 (2020校优秀毕业生，2018研究生数学建模二等奖)   交通银行上海市分公司

• 2021 梁馨月 硕士 上海联影医疗科技有限公司

• 2021 伍君鑫 硕士 交通银行上海市分公司

• 2021 季明媚 学士 (2021上海市优秀毕业生)  复旦大学直升研究生

• 2022 钟佳慧 硕士 支付宝(上海)网络技术有限公司

• 2023 薛润哲 学士 北京协和医学院临床医学直博生

• 2023 孔亚伟 博士 福建省厦门市工业和信息化局